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KMID : 0366220070420030250
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Korean Journal of Hematology
2007 Volume.42 No. 3 p.250 ~ p.257
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FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
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Kim Sang-Ho
Kim Yeo-Kyeoung
Lee Il-Kwon
Jo Deog-Yeon
Moon Jong-Ho
Kwak Jae-Yong
Yim Chang-Yeol
Park Moo-Rim
Yang Deok-Hwan
Cho Sang-Hee
Lee Je-Jung
Chung Ik-Joo
Kim Hyeoung-Joon
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Abstract
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Background:The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance.
Methods:The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated.
Results:Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype.
Conclusion:This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.
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KEYWORD
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FLT3/ITD, Acute myeloid leukemia, Normal karyotype
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